JOURNAL OF SHANDONG UNIVERSITY(NATURAL SCIENCE) ›› 2014, Vol. 49 ›› Issue (1): 31-35.doi: 10.6040/j.issn.1671-9352.0.2013.235

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Novel synthesis of C-terminal polypeptides by ISPPS method

CHEN Lei, JIN Zhi, LIU Qiang, WANG Ming, WANG Pu*   

  1. School of Pharmaceutical Science, Shandong University, Jinan 250012, Shandong, China
  • Received:2013-05-20 Online:2014-01-20 Published:2014-01-15

Abstract:

A facile approach for the preparation of polypeptide C-terminal derivatives by inverse solid phase peptide synthesis (ISPPS) was developed. This novel method combines both advantages of Fmoc-SPPS and TAEC technology, utilizes fewer functional group protection steps. In addition, the reaction can be carried out at room temperature under mild conditions and be easily monitored, and the working-up is simple and efficient. This method is complementary to the direct solid phase peptide synthesis. Several polypeptides as well as their C-terminal derivatives were efficiently prepared by this novel ISPPS method.

Key words: inverse solid phase peptide synthesis (ISPPS), C-terminal derivatives, TAEC, polypeptide

CLC Number: 

  • O629.7
[1] ZHANG Yan, WEI Yu-ping, ZHANG Liang, FU Yan-kai, XU Jian-dong, XU Xia. A novel small peptide ligand for detection of Alzheimer-associated neuronal thread protein [J]. JOURNAL OF SHANDONG UNIVERSITY(NATURAL SCIENCE), 2016, 51(7): 121-125.
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