关键词: 康宁木霉SMF2, peptaibols, 时间杀菌曲线 , MIC, Trichokonins

Abstract: Peptaibols is a kind of Aibriching peptide antibiotics mostly produced by soil fungi and synthesized by nonribosomal peptidesynthetase (NRPS). Trichokonins, with full length of 20 amino acids, belong to the first subfamily of peptaibols. The minimal inhibitory concentration (MIC) of Trichokonins against ordinary Staphylococcus aureus and a multidrug resistant Staphylococcus aureus strain are both 50?μg/mL. It can be observed from the timekilling curves that the multidrug resistant strain shows a higher survival rate in the presence of 50?μg/mL Trichokonins. When they were inoculated for 20 times in 50 μg/mL Trichokonins, the sensitivity of both strains to Trichokonins decreased greatly, and the MICs increased to higher than 200?μg/mL. The results indicate that both strains become resistant to Trichokonins after the treatment. The mechanism of the resistance requires further experimentation for its disagreement with the existing views.

Key words: timebactericidal curvePeptaibols , MIC, Trichokonins, peptaibols, Trichoderma koningii SMF2