甲胎蛋白分子演化的生物信息学分析

甲胎蛋白分子演化的生物信息学分析

郇天笑，王泽，张辉，白增亮^*

山东大学生命科学学院，山东济南250100

收稿日期:2006-09-05 修回日期:1900-01-01 出版日期:2006-10-24 发布日期:2006-10-24
通讯作者: 白增亮

A bioinformatics analysis for the molecular evolution of alpha-fetoprotein

HUAN Tian-xiao, WANG Ze, ZHANG Hui and BAI Zeng-liang^*

Life Science School， Shandong Univ.， Jinan 250100, Shandong， China

Received:2006-09-05 Revised:1900-01-01 Online:2006-10-24 Published:2006-10-24
Contact: BAI Zeng-liang

摘要/Abstract

摘要： 甲胎蛋白（AFP）是类白蛋白家族成员蛋白之一，在生物个体发育以及肝癌发生发展中起重要作用. 为了研究AFP的系统发生，并以此探讨系统发育与个体发育的关系，运用生物信息学手段，分析了不同物种中类白蛋白家族成员的进化关系，并对各分子的白蛋白结构域进行了进化归类.同时，对不同物种的白蛋白（ALB）和AFP之间包含启动子、抑制子和增强子在内的约14?kb的核苷酸序列进行了比较分析. 研究从系统发育的角度阐释了AFP分子及其基因调控机制的演化方式，为更好的认识AFP在机体生理和病理状态的作用建立了理论分析的基础.

关键词: 甲胎蛋白, 类白蛋白基因家族, 进化 , 生物信息学

Abstract: The alpha-fetoprotein (AFP) gene, a member of the albuminoid gene family, plays an important role in individual development. It is also a sign of hepatoma when its concentration is high in the adult. In order to study the polygenesis of AFP and the relationship between individual development and system development, the evolution of the albuminoid gene family was analyzed by analyzing the proteins of the gene family from different species by bioinformatics approaches, and drew a phylogenetic tree of different albumin domains from different proteins. Furthermore, the 14 kb intergenic space sequences were compared between ALB and AFP, including promoters, suppressors and enhancers in 5 different species. The evolution of AFP and its gene regulation mechanism from the point view of the system development were discussed. This research builds the theoretical basis to study the function of alpha-fetoprotein in physiology and pathology.

Key words: evolution , bioinformatics, albuminoid gene family, alpha-fetoprotein

中图分类号:

Q349+.5

郇天笑,王泽,张辉,白增亮* . 甲胎蛋白分子演化的生物信息学分析[J]. J4, 2007, 42(3): 78-83 .

HUAN Tian-xiao,WANG Ze,ZHANG Hui and BAI Zeng-liang* . A bioinformatics analysis for the molecular evolution of alpha-fetoprotein[J]. J4, 2007, 42(3): 78-83 .

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