Abstract: The solvothermal extraction method was used to extract flavones from Ginkgo leaves, and the analysis of the content was completed by HPLC. The dominant factors affecting the leached output were investigated by orthogonal experiments. The optimum conditions determined by the solvothermal method were as follows: the volumetric ratio of ethanol is 70%, the volume of solvent is 40mL when the mass of Ginkgo leaves is 1g and the heating time is 3h. Compared with thermal refluxing extraction, the solvothermal extraction method can provide an efficient, simple and harmless method for obtaining flavones from Ginkgo leaves.

Key words: solvothermal extraction , flavones, Ginkgo leaves