木质纤维素降解酶系的基础和技术研究进展

山东大学学报（理学版） ›› 2011, Vol. 46 ›› Issue (10): 160-170.

木质纤维素降解酶系的基础和技术研究进展

曲音波

山东大学微生物技术国家重点实验室, 山东济南 250100

收稿日期:2011-07-13 出版日期:2011-10-20 发布日期:2011-10-18
作者简介:曲音波(1953- ),男,博士,教授,主要研究方向为纤维素酶和可再生资源微生物转化技术.Email:quyinbo@sdu.edu.cn

Progress in basic and technological research of enzyme system for lignocellulosics biodegradation

QU Yin-bo

State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, Shandong, China

Received:2011-07-13 Online:2011-10-20 Published:2011-10-18

摘要/Abstract

摘要：

山东大学微生物学科从事纤维素降解研究已有五十多年的历史。在木质纤维素微生物降解机理研究的基础上,从自然界中筛选到一株能高效降解植物纤维类生物质的斜卧青霉菌株,并获得该菌的多株抗降解物阻遏纤维素酶高产突变菌株。最近,已完成了对多株斜卧青霉菌株的全基因组测序,正在利用系统生物学技术深入探讨其酶系组成和酶合成调控机理。选育出的高产突变株,已用于规模化生产工业用酶,并开发出玉米芯生物炼制生产纤维素乙醇技术。

关键词: 斜卧青霉, 纤维素乙醇, 生物炼制, 纤维素酶系

Abstract:

Research on cellulose biodegradation has been carried out for more than 50 years in Shandong University. Based on the mechanism studies on microbial degradation of lignocellulosics, a Penicillium decumbens strain, which can hydrolyze lignocellulose efficiently, was isolated from natural samples, and several catabolite repressionresistant mutants were obtained. Genome sequencing of the strains were carried out, and the composition of their enzyme system and the mechanism for regulation of enzyme synthesis were studied by systems biotechnological methods. The cellulase-overproducing mutants has been used for cellulase production in industrial scale, and for cellulosic ethanol production in biorefinery of corncobs.

Key words: cellulases, cellulosic ethanol, biorefinery, Penicillium decumbens

曲音波. 木质纤维素降解酶系的基础和技术研究进展[J]. 山东大学学报（理学版）, 2011, 46(10): 160-170.

QU Yin-bo. Progress in basic and technological research of enzyme system for lignocellulosics biodegradation[J]. JOURNAL OF SHANDONG UNIVERSITY(NATURAL SCIENCE), 2011, 46(10): 160-170.

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