J4 ›› 2009, Vol. 44 ›› Issue (5): 28-32.

• Articles • Previous Articles     Next Articles

Isolation and classification of a Streptomyces netropsis strains SD07 which produces polyene macrolide antibiotics with
 broadspectrum  and high antifungal activity

JIN Jianling, WANG Chong, LEI Tao, GAO Peiji   

  1. State Key Laboratory Of Microbial Technology, School of Life Sciences, Shandong University, Jinan 250100, Shandong, China
  • Received:2008-10-27 Online:2009-05-16 Published:2009-11-18

Abstract:

Streptomyces sp. SD07 was isolated from the soil of the mountain area in the south of Jinan, Shandong province. This strain exhibited broadspectrum and high antifungal activity. Based on the results of preliminary morphological, cultural, physiological and biochemical studies on this strain, and its 16S rDNA sequences, strain SD07 was classified as Streptomyces netropsis. The antifungal compounds CASD07 were extracted from the mycelia and then crystallized,named as CASD07. CASD07 could inhibit many fungi such as Ascomycetes, Basidiomycetes, Zygomycetes and so on. The data from ultravioletvisible absorption and highperformance liquid chromatography / diode array detection (HPLC / DAD) indicated that CASD07 was a mixture of pentaene macrolide and heptaene macrolide antibiotics, and the major compounds were pentaene macrolide antibiotics. CASD07 has wider antifungal spectrum and higher antifungal activity(about two times Amphoteric B).

Key words: Streptomyces netropsis; antifungal antibiotics; pentaene macrolide antibiotics

CLC Number: 

  • R978.5
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