J4 ›› 2011, Vol. 46 ›› Issue (3): 9-12.

• Articles • Previous Articles     Next Articles

Study on the synthesis of Cefuroxime acid with a new phosphoryl active ester

REN Hui-xue1,2, YING Han-jie2, LIU Chang1, JIA Xiang-feng1, YANG Yan-zhao3   

  1. 1. School of Municipal and Environmental Engineering, Shandong Jianzhu University, Jinan 250101, Shandong, China;
     2. College of Life Science and Pharmaceutical Engineering Nanjing University of Technology, Nanjing 210009,  Jiangsu, China;
     3. School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, Shandong, China
  • Received:2010-08-02 Published:2011-04-21


An improved synthesis of cefuroxime acid was presented. High activity with the phosphoryl new active ester of O, O-diethyl phosphorothioic (Z)-2-furyl-2-methoxyimino acetic anhydride (SMIF-DP)replaced the original electropHilic reagents. The cefuroxime acid synthesis route in the 7-bit aminoacylation reaction was improved. The synthetic routes are simplified in the hydrolysis reaction step and complex reaction step. The intermediates are not isolated in the synthetic routes. The one-pot method synthesized 3-decarbamoyl-cefuroxime (DCCF). The total yield of the Cefuroxime acid was 67.7%.

Key words:  phosphoryl active ester; Cefuroxime acid; synthesis

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