Abstract:

An improved synthesis of cefuroxime acid was presented. High activity with the phosphoryl new active ester of O, O-diethyl phosphorothioic (Z)-2-furyl-2-methoxyimino acetic anhydride (SMIF-DP)replaced the original electropHilic reagents. The cefuroxime acid synthesis route in the 7-bit aminoacylation reaction was improved. The synthetic routes are simplified in the hydrolysis reaction step and complex reaction step. The intermediates are not isolated in the synthetic routes. The one-pot method synthesized 3-decarbamoyl-cefuroxime (DCCF). The total yield of the Cefuroxime acid was 67.7％.

Key words:  phosphoryl active ester; Cefuroxime acid; synthesis