类脂液晶中PC对MO构象影响及释放行为

J4 ›› 2010, Vol. 45 ›› Issue (1): 10-16.

类脂液晶中PC对MO构象影响及释放行为

刘少杰迟卫东陆玮洁李真

刘少杰迟卫东陆玮洁李真：山东大学胶体与界面化学教育部重点实验室, 山东济南 250100;
刘少杰：山东省胶体材料工程技术研究中心, 山东济南 250100; 迟卫东：烟台大学, 山东烟台 265000

收稿日期:2009-07-02 出版日期:2010-01-16 发布日期:2010-03-25
作者简介:刘少杰(1961-), 男，研究员，硕士生导师，主要研究方向为胶体与界面化学、阻燃剂化学、有机硅化学. Email:shaojieliu@sdu.edu.cn
基金资助:
山东省自然科学基金重点资助项目（Z2006B03）

Effects of procaine hydrochloride on the molecular conformation ofmonoolein and drug release behavior in the cubic phase

LIU Shao-Jie, CHI Wei-Dong, LIU Wei-Jie, LI Zhen：Key Laboratory of Colloid and Interface Chemistry of Education Ministry, Shandong University, Jinan 250013, Shandong, China;
LIU Shao-Jie： Engineering research Center for Colloid Materials of Shandong Province, Jinan 250100, Shandong, China;
CHI Wei-Dong： Yantai University, Yantai 265000, Shandong, China

Received:2009-07-02 Online:2010-01-16 Published:2010-03-25

摘要/Abstract

摘要：

利用傅立叶变换红外光谱(FT-IR)技术研究了盐酸普鲁卡因(PC)对类脂立方液晶中甘油单油酸酯(MO)分子构象的影响。研究表明,PC对MO分子疏水部分的影响较大,同时促进了MO分子极性头中羰基的氢键作用,证明PC可以参与形成脂质双层膜。同时研究了PC在MO／水立方液晶中的释放行为,发现PC浓度不同时,其释放行为相似,释放的两个阶段都符合Higuchi平方根定律。

关键词: 盐酸普鲁卡因;类脂立方液晶;FT-IR;药物释放

Abstract:

The effect of procaine hydrochloride (PC) on the molecular conformation of monoolein in the cubic liquid crystalline phase was studied by FT-IR. It was found that the conformation of the hydrophobic group of monoolein was strongly affected by PC, and the Hbond between MO and PC could induce a change of the vibrations of C=O bond in the polar group of the MO. The release behaviors of PC fromMO／water cubic phases with different PC contents were after investigation found to be similar and corresponded to the Higuchi quarter root law.

Key words: procaine hydrochloride; cubic liquid crystalline; FT-IR; drug release

刘少杰迟卫东陆玮洁李真. 类脂液晶中PC对MO构象影响及释放行为[J]. J4, 2010, 45(1): 10-16.

LIU Shao-Jie, CHI Wei-Dong, LIU Wei-Jie, LI Zhen. Effects of procaine hydrochloride on the molecular conformation ofmonoolein and drug release behavior in the cubic phase[J]. J4, 2010, 45(1): 10-16.

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