大蓟水煎剂治疗小鼠高血压的研究

J4 ›› 2011, Vol. 46 ›› Issue (7): 7-10.

大蓟水煎剂治疗小鼠高血压的研究

王振平,毕佳,陈忠科

山东大学生命科学学院, 山东济南 250100

收稿日期:2010-10-28 出版日期:2011-07-20 发布日期:2011-09-08
通讯作者: 陈忠科(1962- ),男,副教授,主要从事发育生物学和生理学研究. Email:zhongkechen@sdu.edu.cn
作者简介:王振平(1968- ),男,硕士研究生,副教授,主要从事发育生物学研究.Email:wangzhenping100@163.com
基金资助:
山东省卫生厅基金资助项目(HZ021)

Study of the treatment of hypertension in mice with the Cirsium japonicum DC decoction

WANG Zhenping, BI Jia, CHEN Zhongke

School of Life Scince, Shandong University, Jinan 250100, Shandong, China

Received:2010-10-28 Online:2011-07-20 Published:2011-09-08

摘要/Abstract

摘要：

利用本研究室构建的小鼠高血压模型,研究了大蓟水煎剂对高血压小鼠的降压作用以及对心脏、肾脏等器官的影响,同时检测对凝血的影响。结果表明:适量的大蓟水煎剂灌胃高血压模型小鼠,可显著降低血压至近正常值;大蓟水煎剂对心、肝、肾、脾、胸腺等的脏器体重比无显著影响,但高血压组肾脏和心脏组织细胞密度增大,肾小囊显著变小,治疗组肾脏中肾小囊恢复近正常值,肾脏和心脏组织细胞密度基本恢复正常;大蓟水煎剂治疗的小鼠凝血时间显著缩短。结论:适量的大蓟水煎剂灌胃高血压模型小鼠具有显著降压效应,对心脏和肾脏等内脏器官有较好的保护作用;大蓟增强凝血能力,而且与剂量成正相关性,因此用药量要适度。

关键词: 大蓟;水煎剂;血压;高血压模型小鼠;凝血

Abstract:

In this study, the effects of Cirsium japonicum DC decoction (CJDC) on antihypertension, the structure and weight of heart, kidney and other organs in mice model of hypertension were explored, and the blood coagulation was also detected. The results showed that a moderate dose of CJDC could significantly reduce the blood pressure to the normal level in hypertensive mice, and no significant effects were found on the ratios of viscera to body of heart, liver, kidney, spleen and thymus. There were significant increases in the density of kidney and heart tissue and decreases in renal capsule in hypertensive mice, which returned to the normal level in treatment mice. CJDC could also significantly shorten the time of blood coagulation in treatment mice. Conclusion: A moderate dose of CJDC could significantly lower the blood pressure as well as protect heart and kidney better in treatment mice. It also increased hemostatic with positive correlation to the dose, so the dosage should be appropriate.

Key words: Cirsium japonicum DC; decoction; blood pressure; the mice model of hypertension; blood coagulation

王振平,毕佳,陈忠科. 大蓟水煎剂治疗小鼠高血压的研究[J]. J4, 2011, 46(7): 7-10.

WANG Zhenping, BI Jia, CHEN Zhongke. Study of the treatment of hypertension in mice with the Cirsium japonicum DC decoction[J]. J4, 2011, 46(7): 7-10.

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