滚压载荷下关节软骨的溶质传递

doi:10.6040/j.issn.1671-9352.0.2014.198

山东大学学报（理学版） ›› 2015, Vol. 50 ›› Issue (01): 81-84.doi: 10.6040/j.issn.1671-9352.0.2014.198

滚压载荷下关节软骨的溶质传递

王龙韬^1,2, 杨秀萍^1,2, 刘清², 杨文静³, 范振敏², 张春秋²

1. 天津理工大学天津市先进机电系统设计与智能控制重点实验室, 天津 300384;
2. 天津理工大学机械工程学院, 天津 300384;
3. 天津市职工医院药剂科, 天津 300005

收稿日期:2014-05-04 修回日期:2014-10-22 出版日期:2015-01-20 发布日期:2015-01-24
通讯作者: 张春秋(1968-),男,博士后,教授,研究方向为生物力学.E-mail:zhang_chunqiu@126.com E-mail:zhang_chunqiu@126.com
作者简介:王龙韬(1989-),男,硕士研究生,研究方向为关节软骨.E-mail:hugedragon828@sina.com
基金资助:
国家自然科学基金资助项目(11172208);国家自然科学重点基金资助项目(11432016);国家自然科学基金青年基金资助项目(11402172)

Solute transport in articular cartilage under rolling-compressing load

WANG Long-tao^1,2, YANG Xiu-ping^1,2, LIU Qing², YANG Wen-jing³, FAN Zhen-min², ZHANG Chun-qiu²

1. Tianjin Key Laboratory of the Design and Intelligent Control of the Advanced Mechatronical System, Tianjin 300384, China;
2. School of Mechanical Engineering, Tianjin University of Technology, Tianjin 300384, China;
3. Pharmacy Department, Tianjin Worker's Hospital, Tianjin 300005, China

Received:2014-05-04 Revised:2014-10-22 Online:2015-01-20 Published:2015-01-24

摘要/Abstract

摘要： 为研究关节软骨在滚压载荷下溶质的扩散行为,取成年猪关节软骨,用异硫氰酸荧光素-右旋糖酐标记,分别观察在滚压载荷和静置状态下,软骨中溶质荧光强度随时间和软骨层位置的变化,得到相对浓度和扩散系数的变化规律。结果表明,滚压载荷样本B的溶质相对浓度始终大于静置状态样本A,平均值最大相差62.4%,随时间增加,B组软骨中层和深层相对浓度比A组增加明显;B组扩散系数高于A组,平均值最大相差93%,随时间增加,B组软骨中间层扩散系数比A组显著增加。因此,滚压载荷可以促进关节软骨的溶质传递,提高溶质的扩散系数,特别是对中层和深层影响显著。

关键词: 滚压载荷, 关节软骨, 溶质, 浓度, 扩散系数

Abstract: In order to study solute transport behavior of articular cartilage under rolling-compressing load, mature pig articular cartilages were marked by Fluorescein isothiocyanate-Dextran, their solute fluorescence intensity change with time and cartilage depth was observed under rolling-compressing load and static state respectively. The changing laws of relative concentration and diffusivity were obtained. The results show that solute relative concentration under rolling-compressing load (sample B) is larger than that under static state (sample A), and average maximum is 62.4% difference. Relative concentration in transitional and deep layers of sample B increases more significantly than that of sample A with time increasing. Diffusivity of sample B is larger than that of sample A, and average maximum is 93% difference. Diffusivity in transitional and deep layer of sample B increases more conspicuously than that of sample A with time increasing. So rolling-compressing load can promote solute transport, and improve solute diffusivity in articular cartilage, especially in transitional and deep layers.

Key words: diffusivity, rolling-compressing load, solute, articular cartilage, concentration

中图分类号:

R318.01

王龙韬, 杨秀萍, 刘清, 杨文静, 范振敏, 张春秋. 滚压载荷下关节软骨的溶质传递[J]. 山东大学学报（理学版）, 2015, 50(01): 81-84.

WANG Long-tao, YANG Xiu-ping, LIU Qing, YANG Wen-jing, FAN Zhen-min, ZHANG Chun-qiu. Solute transport in articular cartilage under rolling-compressing load[J]. JOURNAL OF SHANDONG UNIVERSITY(NATURAL SCIENCE), 2015, 50(01): 81-84.

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滚压载荷下关节软骨的溶质传递

Solute transport in articular cartilage under rolling-compressing load

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