类脂液晶中PC对MO构象影响及释放行为

J4 ›› 2010, Vol. 45 ›› Issue (1): 10-16.

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Effects of procaine hydrochloride on the molecular conformation ofmonoolein and drug release behavior in the cubic phase

LIU Shao-Jie, CHI Wei-Dong, LIU Wei-Jie, LI Zhen：Key Laboratory of Colloid and Interface Chemistry of Education Ministry, Shandong University, Jinan 250013, Shandong, China;
LIU Shao-Jie： Engineering research Center for Colloid Materials of Shandong Province, Jinan 250100, Shandong, China;
CHI Wei-Dong： Yantai University, Yantai 265000, Shandong, China

Received:2009-07-02 Online:2010-01-16 Published:2010-03-25

Abstract

Abstract:

The effect of procaine hydrochloride (PC) on the molecular conformation of monoolein in the cubic liquid crystalline phase was studied by FT-IR. It was found that the conformation of the hydrophobic group of monoolein was strongly affected by PC, and the Hbond between MO and PC could induce a change of the vibrations of C=O bond in the polar group of the MO. The release behaviors of PC fromMO／water cubic phases with different PC contents were after investigation found to be similar and corresponded to the Higuchi quarter root law.

Key words: procaine hydrochloride; cubic liquid crystalline; FT-IR; drug release

LIU Shao-Jie, CHI Wei-Dong, LIU Wei-Jie, LI Zhen. Effects of procaine hydrochloride on the molecular conformation ofmonoolein and drug release behavior in the cubic phase[J].J4, 2010, 45(1): 10-16.