Abstract:

The cytotoxicity of the functionalized multi-walled carbon nanotubes (f-MWCNTs) library, previously synthesized by our group, to normal human fibroblasts (NHFB) was investigated by WST-1 assay. The effects of selected f-MWCNTs with different cytotoxicity on cellular uptake and proliferation, and oxidative stress in NHFB were studied. It was  found that different surface modification of MWCNTs could lead to different cytotoxicity, and  f-MWCNTs could be uptaken by NHFB and induce cytotoxity and reactive oxygen species in NHFB in a dose dependent manner.
 

Key words: functionalized multi-walled carbon nanotubes; cytotoxicity; oxidative stress