In this study, the effects of Cirsium japonicum DC decoction (CJDC) on antihypertension, the structure and weight of heart, kidney and other organs in mice model of hypertension were explored, and the blood coagulation was also detected. The results showed that a moderate dose of CJDC could significantly reduce the blood pressure to the normal level in hypertensive mice, and no significant effects were found on the ratios of viscera to body of heart, liver, kidney, spleen and thymus. There were significant increases in the density of kidney and heart tissue and decreases in renal capsule in hypertensive mice, which returned to the normal level in treatment mice. CJDC could also significantly shorten the time of blood coagulation in treatment mice. Conclusion: A moderate dose of CJDC could significantly lower the blood pressure as well as protect heart and kidney better in treatment mice. It also increased hemostatic with positive correlation to the dose, so the dosage should be appropriate.