《山东大学学报(理学版)》 ›› 2024, Vol. 59 ›› Issue (4): 108-116.doi: 10.6040/j.issn.1671-9352.0.2022.465
• • 上一篇
王淑影,张亚男,程云飞,周丽芳*
WANG Shuying, ZHANG Yanan, CHENG Yunfei, ZHOU Lifang*
摘要: 在已有生存分析研究中,大多直接假设响应变量与指定协变量的模型形式,进而估计协变量效应,但当模型假设错误时,对应的结论可能是错误的。因此,为了避免指定协变量构建模型引起的不准确性,考虑使用一种基于模型平均方法的加速失效时间模型来对带治愈组的右删失数据进行刻画。在极大似然估计的框架下,采用基于信息准则的模型选择和模型平均方法进行统计推断研究。数值模拟结果显示,在带治愈组的右删失数据下基于模型平均方法的加速失效时间(accelerated failure time, AFT)模型估计及预测精度高于模型选择方法。最后通过黑色素瘤临床试验数据的分析,对所提方法的可行性和实用性进行验证。
中图分类号:
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