J4

• Articles • Previous Articles     Next Articles

The vacuolization and differentiation of vascular endothelial cells by a γ-butyrolactones derivative

JING Qing-chuan1， ZHAO Jing2， ZHAO Bao-xiang3*，ZHANG Shang-li2，MIAO Jun-ying2*   

  1. 1. Institute of Poultry Science, Shandong Academy of Agricultural Sciences;2. Institute of Development Biology, College of Life Science, Shandong University;3. Institute of Organic Chemistry, School of Chemistry and Chemical Engineering
  • Received:1900-01-01 Revised:1900-01-01 Online:2006-10-24 Published:2006-10-24
  • Contact: JING Qing-chuan

PDF (PC)

1236

Abstract: The effects of vacuolization on the differentiation of vascular endothelial cells were analyzed from a chemical biochemistry genetics perspective using the blastodisc cells differentiation model induced by FGF with the γ-butyrolactones derivative. The results of neutral red staining and acridine orange staining show that the vacuoles are acid, γ-butyrolactones derivative can suppress the differentiation of chick blastodisc cells to vascular endothelial cells by inhibiting the acid vacuoles in cells. The data validates the effect of vacuolizationon cell differentiation, which can be regarded as a reference for future research on the target protein functions of γ-butyrolactones derivative in chick blastodisc cells differentiation to endothelial cells.

Key words: γ-butyrolactones derivative , chemical genetics, differentiation of endothelial cell, vacuoles, chick blastodisc cell

CLC Number: 

  • Q2
[1] SHEN Jian-lin, CHEN Dong-hua. Mitochondrial pyruvate carrier3 mediates abscisic acid-regulated stomatal closure and the drought response [J]. JOURNAL OF SHANDONG UNIVERSITY(NATURAL SCIENCE), 2018, 53(7): 1-6.
[2] WEN Qian, FAN Ting-jun. UVB damage and protection effect of ascorbic acid on human corneal endothelial cells in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY(NATURAL SCIENCE), 2015, 50(09): 1-6.
[3] GUO JI-wei, JIN Dan. Degradation of co-activator Yki of the hippo pathway through ubiquitinationby Slimb [J]. JOURNAL OF SHANDONG UNIVERSITY(NATURAL SCIENCE), 2015, 50(01): 37-41.
[4] GAO Jin-fang1,2, LIU Zong-zheng1,2, WEI Lin-gai1,2, ZHOU Huan-min1,2, ZHANG Yan-ru1,2﹡, CAO Jun-wei1,2. Isolation, culture and multiple differentiation induction of mongolia sheep#br# adipose tissue-derived mesenchymal stem cells [J]. JOURNAL OF SHANDONG UNIVERSITY(NATURAL SCIENCE), 2014, 49(1): 20-24.
[5] YUE Jiang, CHANG Da-Wei. Preconditioned simultaneous displacement(PSD) method for rank deficient  linear systems [J]. J4, 2009, 44(10): 30-35.
[6] HUANG Shu-hong＃,YANG Ling＃,XIE Guo-rui,ZHANG Hong-wei* . The expression of the Rab23 protein in different organs of mice [J]. J4, 2008, 43(1): 1-03 .
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of JOURNAL OF SHANDONG UNIVERSITY(NATURAL SCIENCE)
Supported by Beijing Magtech Co.Ltd