JOURNAL OF SHANDONG UNIVERSITY(NATURAL SCIENCE) ›› 2023, Vol. 58 ›› Issue (7): 18-31.doi: 10.6040/j.issn.1671-9352.0.2021.417

Previous Articles     Next Articles

R&D innovation strategy and behavior choice of competition drug supply chain

Yan WEN*(),Xiyuan YU,Jinsong HU   

  1. School of Business, Qingdao University, Qingdao 266071, Shandong, China
  • Received:2021-06-09 Online:2023-07-20 Published:2023-07-05
  • Contact: Yan WEN E-mail:wenyan@qdu.edu.cn

RichHTML

4

PDF (PC)

230

Abstract:

Based on the short-sighted and far-sighted behaviors of members of competitive drug supply chain, four dynamic differential game models were constructed to study the influences of different behavior choices, changes in competition intensity and reimbursement ratio of medical insurance on drug manufacturers' R & D innovation investment, medical institution' cost-sharing strategies and supply chain performance. The study found that although the competition between drug manufacturers harms the profits of short-sighted manufacturer, it increases the overall performance of the drug supply chain and promotes the higher R & D innovation investment of far-sighted manufacturer. With higher reimbursement rate, both far-sighted drug manufacturer and medical institution have increased their profits, but not short-sighted drug manufacturer. In addition, medical institution sharing costs with one manufacturer would depress the profits of the other, when medical institution choose the behavior mode of sharing drug R & D innovation costs for two competing manufacturers simultaneously, they can benefit the profits of all members of the drug supply chain.

Key words: short-sighted and far-sighted behaviors, cost sharing, differential game, drug supply chain, competing manufacturer

CLC Number: 

  • F224

Fig.1

The structure of competitive drug supply chain"

Table 1

Meaning of key parameters in the model"

参数(i=1, 2) 含义
wi 制造商生产单位药品的边际利润
pi 医疗机构销售单位药品的边际价格
ρ 贴现因子
λ 研发创新投入对品牌商誉的影响因子
δ 制造商品牌商誉衰减系数
θ 扣除医保报销比例后的自付比例
m 医疗机构对制造商M1生产药品的推荐意愿
α、β、γ 边际价格、研发创新投入、品牌商誉分别对需求的影响因子
d 研发创新投入差异对需求的影响因子, 体现了制造商间的竞争强度
决策变量 Ii(t) t时刻的药品制造商研发创新投入
ϕ、Φ 医疗机构对制造商M1、M2的成本分担比例
状态变量 Gi(t) t时刻的制造商品牌商誉

Table 2

The impact of health insurance reimbursement ratio on supply chain performance"

1-θ VSSM1 VM2SS VRSS VFSM1 VM2FS VRFS VSFM1 VSFM2 VRSF VFFM1 VFFM2 VRFF
↑ - ↑ ↑ - ↑ ↑ - ↑ ↑ - ↑ ↑
↓ - ↓ ↓ - ↓ ↓ - ↓ ↓ - ↓ ↓

Fig.2

Impact of competition intensity on member strategies"

Fig.3

Impact of competition intensity on brand goodwill"

Fig.4

Impact of competition intensity on supply chain profit"

1 TANG X L , DU J . The performance of China's biomedical innovation: a scientometric analysis[J]. Science China Life Sciences, 2016, 59 (10): 1074- 1082.
doi: 10.1007/s11427-016-5078-6
2 YE X , WANG Q L , WANG H X . New era of drug innovation in China[J]. Acta Pharmaceutica Sinica B, 2019, 9 (5): 1084- 1085.
doi: 10.1016/j.apsb.2019.06.002
3 陈晓春, 张文松, 顾维军. 考虑技术研发和物流配送的医药供应链组合契约协调模型研究[J]. 中国管理科学, 2020, 28 (3): 80- 92.
doi: 10.16381/j.cnki.issn1003-207x.2020.03.009
CHEN Xiaochun , ZHANG Wensong , GU Weijun . Research on the coordination model of pharmaceutical supply chain considering technology R & D and logistics distribution full text replacement[J]. Chinese Journal of Management Science, 2020, 28 (3): 80- 92.
doi: 10.16381/j.cnki.issn1003-207x.2020.03.009
4 李亚林, 来小鹏. 美国药品专利保护期延长制度研究[J]. 中国新药杂志, 2020, 29 (4): 361- 366.
doi: 10.3969/j.issn.1003-3734.2020.04.001
LI Yalin , LAI Xiaopeng . Study on patent term extension of U.S.A[J]. Chinese Journal of New Drugs, 2020, 29 (4): 361- 366.
doi: 10.3969/j.issn.1003-3734.2020.04.001
5 THANIGAIMALAI Pillaiyar . A medicinal chemistry perspective of drug repositioning: recent advances and challenges in drug discovery[J]. European Journal of Medicinal Chemistry, 2020, 195, 112275.
doi: 10.1016/j.ejmech.2020.112275
6 陈志洪, 徐宏. 中国药品集中采购政策解读与实证分析[J]. 系统管理学报, 2021, 30 (1): 170- 179.
CHEN Zhihong , XU Hong . Theoretical interpretations and empirical analyses of China's drug volume-based procurement reform[J]. Journal of Systems & Management, 2021, 30 (1): 170- 179.
7 HASSAN Benchekroun . Could myopic pricing be a strategic choice in marketing channels? A game theoretic analysis[J]. Journal of Economic Dynamics and Control, 2009, 33 (9): 1699- 1718.
doi: 10.1016/j.jedc.2009.03.005
8 LU F X , LIU G W , ZHANG J X , et al. Benefits of partial myopia in a durable product supply chain considering pricing and advertising[J]. Journal of the Operational Research Society, 2016, 67 (10): 1309- 1324.
doi: 10.1057/jors.2016.27
9 WANG J , CHENG X X , WANG X Y , et al. Myopic versus farsighted behaviors in a low-carbon supply chain with reference emission effects[J]. Complexity, 2019, 2019, 1- 15.
10 LIU G W , SETHI S P , ZHANG J X . Myopic vs. far-sighted behaviours in a revenue-sharing supply chain with reference quality effects[J]. International Journal of Production Research, 2016, 54 (5): 1334- 1357.
doi: 10.1080/00207543.2015.1068962
11 LU F X , TANG W S , LIU G W , et al. Cooperative advertising: a way escaping from the prisoner's dilemma in a supply chain with sticky price[J]. Omega, 2019, 86, 87- 106.
doi: 10.1016/j.omega.2018.07.003
12 JOHARI M , HOSSEINI-MOTLAGH S M . Coordination contract for a competitive pharmaceutical supply chain considering corporate social responsibility and pricing decisions[J]. RAIRO-Operations Research, 2020, 54 (5): 1515- 1535.
doi: 10.1051/ro/2019073
13 Anshuman , Chutani . Dynamic cooperative advertising under manufacturer and retailer level competition[J]. European Journal of Operational Research, 2018, 268 (2): 635- 652.
doi: 10.1016/j.ejor.2018.02.027
14 杨艳, 程燕培, 陈收. 不同权力结构下供应链企业社会责任激励[J]. 中国管理科学, 2019, 27 (3): 144- 156.
doi: 10.16381/j.cnki.issn1003-207x.2019.03.015
YANG Yan , CHENG Yanpei , CHEN Shou . Stimulating corporate social responsibility in supply chain in different dominated modes[J]. Chinese Journal of Management Science, 2019, 27 (3): 144- 156.
doi: 10.16381/j.cnki.issn1003-207x.2019.03.015
15 胡劲松, 刘玉红, 马德青. 技术创新下考虑绿色度和溯源商誉的食品供应链动态策略[J]. 软科学, 2021, 35 (1): 39- 49.
doi: 10.3969/j.issn.1003-2800.2021.01.010
HU Jinsong , LIU Yuhong , MA Deqing . Dynamic strategy of food supply chain considering greenness and traceability goodwill under technological innovation[J]. Soft Science, 2021, 35 (1): 39- 49.
doi: 10.3969/j.issn.1003-2800.2021.01.010
16 曹裕, 胡韩莉, 李青松. 成本分担契约下绿色供应链的环境标签策略选择研究[J]. 中国管理科学, 2022, 30 (10): 119- 129.
CAO Yu , HU Hanli , LI Qingsong . Research on environmental labeling strategy selection of green supply chain under cost sharing contract[J]. Chinese Journal of Management Science, 2022, 30 (10): 119- 129.
17 孟庆春, 于宇, 金宗凯, 等. 考虑信息平台影响的供应链联合研发策略研究[J]. 山东大学学报(理学版), 2021, 56 (10): 149- 158.
MENG Qingchun , YU Yu , JIN Zongkai , et al. Research on supply chain joint R & D strategy considering the influence of information platform[J]. Journal of Shandong University(Natural Science), 2021, 56 (10): 149- 158.
18 李伟, 李凯. 考虑渠道势力和研发溢出的竞争制造商研发决策研究[J]. 中国管理科学, 2019, 27 (5): 196- 207.
doi: 10.16381/j.cnki.issn1003-207x.2019.05.020
LI Wei , LI Kai . The innovation decisions of competitive manufactures when considering channel power and spillover[J]. Chinese Journal of Management Science, 2019, 27 (5): 196- 207.
doi: 10.16381/j.cnki.issn1003-207x.2019.05.020
19 HUANG Zongsheng . Dynamic cooperative promotion models with competing retailers and negative promotional effects on brand image[J]. Computers & Industrial Engineering, 2018, 118, 291- 308.
20 许明辉, 刘晚霞. 制造商竞争环境下基于要素品牌战略的动态合作广告研究[J]. 管理工程学报, 2019, 33 (3): 162- 169.
doi: 10.13587/j.cnki.jieem.2019.03.019
XU Minghui , LIU Wanxia . Dynamic cooperative advertising with competitive manufacturers based on ingredient branding strategy[J]. Journal of Industrial Engineering and Engineering Management, 2019, 33 (3): 162- 169.
doi: 10.13587/j.cnki.jieem.2019.03.019
21 李凯, 李伟, 安岗. 链与链竞争背景下的制造商定价策略[J]. 系统管理学报, 2017, 26 (4): 771- 778.
LI Kai , LI Wei , AN Gang . Manufacturers' pricing decisions under the chain-to-chain competition[J]. Journal of Systems & Management, 2017, 26 (4): 771- 778.
22 纪雅杰, 马德青, 胡劲松. 消费者参考质量存在时滞效应的动态质量改进策略[J]. 山东大学学报(理学版), 2020, 55 (9): 89- 101.
JI Yajie , MA Deqing , HU Jinsong . Dynamic quality improvement strategies with delay effect in consumer reference quality[J]. Journal of Shandong University (Natural Science), 2020, 55 (9): 89- 101.
23 NERLOVE M , ARROW K J . Optimal advertising policy under dynamic conditions[J]. Economica, 1962, 29 (114): 129.
doi: 10.2307/2551549
24 杨丹丹, 侯文华. 考虑渠道竞争和医保政策的医药供应链双渠道定价策略[J]. 管理学报, 2019, 16 (6): 932- 938.
doi: 10.3969/j.issn.1672-884x.2019.06.016
YANG Dandan , HOU Wenhua . Pricing strategy of dual-channel pharmaceutical supply chain under channel competition and health insurance compensation[J]. Chinese Journal of Management, 2019, 16 (6): 932- 938.
doi: 10.3969/j.issn.1672-884x.2019.06.016
25 MARIA A , FRUTOS D . Competition in the pharmaceutical industry: how do quality differences shape advertising strategies?[J]. Journal of Health Economics, 2013, 32 (1): 268- 285.
doi: 10.1016/j.jhealeco.2012.07.006
26 荣俊美, 朱立龙. 政府管制下双渠道药品供应链质量控制策略[J]. 系统工程, 2019, 37 (5): 99- 108.
doi: 10.3969/j.issn.1001-2362.2019.05.073
RONG Junmei , ZHU Lilong . The quality control strategy of dual-channel drug supply chain under government regulation[J]. Systems Engineering, 2019, 37 (5): 99- 108.
doi: 10.3969/j.issn.1001-2362.2019.05.073
27 周艳菊, 叶欣, 詹结祥, 等. 制造商竞争与合作下双渠道供应链联合减排的微分博弈分析[J]. 控制与决策, 2018, 33 (11): 2021- 2028.
doi: 10.13195/j.kzyjc.2017.0818
ZHOU Yanju , YE Xin , ZHAN Jiexiang , et al. Differential game model of joint emission reduction strategies in a dual-channel supply chain considering manufacturers' competition and cooperation[J]. Control and Decision, 2018, 33 (11): 2021- 2028.
doi: 10.13195/j.kzyjc.2017.0818
28 李诗杨, 但斌, 李红霞. 公益性和自我药疗影响下的药品供应链定价与双渠道策略[J]. 管理学报, 2017, 14 (8): 1227- 1235.
doi: 10.3969/j.issn.1672-884x.2017.08.014
LI Shiyang , DAN Bin , LI Hongxia . Pricing and dual-channel strategies in pharmaceutical supply chain influence on public welfare and self-medication[J]. Chinese Journal of Management, 2017, 14 (8): 1227- 1235.
doi: 10.3969/j.issn.1672-884x.2017.08.014
[1] JIANG Ji-kun, LI Yu, WANG Wei-hao. Influence of altruistic behaviors upon service and pricing decisions of dynamic supply chain [J]. JOURNAL OF SHANDONG UNIVERSITY(NATURAL SCIENCE), 2022, 57(5): 97-110.
[2] ZHANG Ke-yong, ZHANG Na. Green supply chain pricing and coordination with reciprocal preferences under government subsidies [J]. JOURNAL OF SHANDONG UNIVERSITY(NATURAL SCIENCE), 2022, 57(1): 30-41.
[3] De-qing MA,Jin-song HU. Dynamic quality improvement strategies with delay effect in consumer reference quality [J]. JOURNAL OF SHANDONG UNIVERSITY(NATURAL SCIENCE), 2020, 55(9): 101-89.
[4] ZHANG Ke-yong, LI Chun-xia, YAO Jian-ming, LI Jiang-xin. Decision-making and coordination of green supply chain with risk aversion under government subsidies [J]. JOURNAL OF SHANDONG UNIVERSITY(NATURAL SCIENCE), 2019, 54(11): 35-51.
[5] TIAN Shuang-liang1, FANG Bao-yan1*, WANG Zhi-gang2. Approximation method for two-point boundary value problem of differential game based on ridge basis function [J]. J4, 2011, 46(8): 38-41.
[6] WANG Guang-chen . LQ nonzero sum stochastic differential game under partial observable information [J]. J4, 2007, 42(6): 12-15 .
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] TANG Feng-qin1, BAI Jian-ming2. The precise large deviations for a risk model with extended negatively upper orthant dependent claim  sizes[J]. J4, 2013, 48(1): 100 -106 .
[2] CHENG Zhi1,2, SUN Cui-fang2, WANG Ning1, DU Xian-neng1. On the fibre product of Zn and its property[J]. J4, 2013, 48(2): 15 -19 .
[3] TANG Xiao-hong1, HU Wen-xiao2*, WEI Yan-feng2, JIANG Xi-long2, ZHANG Jing-ying2, SHAO Xue-dong3. Screening and biological characteristics studies of wide wine-making yeasts[J]. JOURNAL OF SHANDONG UNIVERSITY(NATURAL SCIENCE), 2014, 49(03): 12 -17 .
[4] LUO Si-te, LU Li-qian, CUI Ruo-fei, ZHOU Wei-wei, LI Zeng-yong*. Monte-Carlo simulation of photons transmission at alcohol wavelength in  skin tissue and design of fiber optic probe[J]. J4, 2013, 48(1): 46 -50 .
[5] TIAN Xue-gang, WANG Shao-ying. Solutions to the operator equation AXB=C[J]. J4, 2010, 45(6): 74 -80 .
[6] HUO Yu-hong, JI Quan-bao. Synchronization analysis of oscillatory activities in a biological cell system[J]. J4, 2010, 45(6): 105 -110 .
[7] ZHAO Jun1, ZHAO Jing2, FAN Ting-jun1*, YUAN Wen-peng1,3, ZHANG Zheng1, CONG Ri-shan1. Purification and anti-tumor activity examination of water-soluble asterosaponin from Asterias rollestoni Bell[J]. J4, 2013, 48(1): 30 -35 .
[8] YANG Yong-wei1, 2, HE Peng-fei2, LI Yi-jun2,3. On strict filters of BL-algebras#br#[J]. JOURNAL OF SHANDONG UNIVERSITY(NATURAL SCIENCE), 2014, 49(03): 63 -67 .
[9] LI Min1,2, LI Qi-qiang1. Observer-based sliding mode control of uncertain singular time-delay systems#br#[J]. JOURNAL OF SHANDONG UNIVERSITY(NATURAL SCIENCE), 2014, 49(03): 37 -42 .
[10] HE Hai-lun， CHEN Xiu-lan* . Circular dichroism detection of the effects of denaturants and buffers on the conformation of cold-adapted protease MCP-01 and  mesophilic protease BP01[J]. JOURNAL OF SHANDONG UNIVERSITY(NATURAL SCIENCE), 2013, 48(1): 23 -29 .
Copyright 2018 © Editorial office of JOURNAL OF SHANDONG UNIVERSITY(NATURAL SCIENCE)
Supported by Beijing Magtech Co.Ltd