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The vacuolization and differentiation of vascular endothelial cells by a γ-butyrolactones derivative

JING Qing-chuan1， ZHAO Jing2， ZHAO Bao-xiang3*，ZHANG Shang-li2，MIAO Jun-ying2*   

  1. 1. Institute of Poultry Science, Shandong Academy of Agricultural Sciences;2. Institute of Development Biology, College of Life Science, Shandong University;3. Institute of Organic Chemistry, School of Chemistry and Chemical Engineering
  • Received:1900-01-01 Revised:1900-01-01 Online:2006-10-24 Published:2006-10-24
  • Contact: JING Qing-chuan

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Abstract: The effects of vacuolization on the differentiation of vascular endothelial cells were analyzed from a chemical biochemistry genetics perspective using the blastodisc cells differentiation model induced by FGF with the γ-butyrolactones derivative. The results of neutral red staining and acridine orange staining show that the vacuoles are acid, γ-butyrolactones derivative can suppress the differentiation of chick blastodisc cells to vascular endothelial cells by inhibiting the acid vacuoles in cells. The data validates the effect of vacuolizationon cell differentiation, which can be regarded as a reference for future research on the target protein functions of γ-butyrolactones derivative in chick blastodisc cells differentiation to endothelial cells.

Key words: γ-butyrolactones derivative , chemical genetics, differentiation of endothelial cell, vacuoles, chick blastodisc cell

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