关键词: 基因调控网络, 贝叶斯网络, 生物信息学 , 模型, 转录模块

Abstract: Transcriptive regulatory networks are the global representation of multiple interactions between genes and their products, which can help us understand the cell's function at the level of gene expression. Recent research advances in multiple bioinformatics (computational molecular biology) and highthroughout experimental technologies have made the reconstruction of transcriptive regulatory networks possible. The study of transcriptive regulatory networks intends to infer regulations between genes from microarray data, and reveals the complex life of cell. Also far from being completed, the ability to recreate transcriptive regulatory networks from available experimental data facilitates the systematic dissection of cell function. The research of transcriptive regulatory networks is an important topic in functional genomics, and one of the most challenging questions in the front of bioinformatics and system biology. Several typical mathematical models and their new research developments are discussed concisely.

Key words: bioinformatics , model, transcriptive modules, Bayesian networks, transcriptive regulatory networks