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《山东大学学报(理学版)》 ›› 2025, Vol. 60 ›› Issue (10): 141-149.doi: 10.6040/j.issn.1671-9352.0.2025.062

• • 上一篇    

表面活性剂和纳米颗粒稳定的双重乳液凝胶

蒋晓倩1,孙秀萍2,宋爱新1*   

  1. 1.山东大学胶体与界面化学教育部重点实验室, 山东 济南 250100;2.山东海化集团有限公司, 山东 潍坊 262737
  • 发布日期:2025-10-17
  • 通讯作者: 宋爱新(1974— ),女,教授,研究方向为胶体与界面化学. E-mail:songaixin@sdu.edu.cn
  • 作者简介:蒋晓倩(1999— ),女,硕士研究生,研究方向为胶体与界面化学. E-mail:202232260@mail.sdu.edu.cn*通信作者:宋爱新(1974— ),女,教授,研究方向为胶体与界面化学. E-mail:songaixin@sdu.edu.cn
  • 基金资助:
    国家自然科学基金资助项目(22372090);山东省自然科学基金项目(ZR2023QB154)

Double emulsion gels stabilized by surfactants and nanoparticles

JIANG Xiaoqian1, SUN Xiuping2, SONG Aixin1*   

  1. 1. Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, Shandong University, Jinan 250100, Shandong, China;
    2. Shandong Haihua Group Co., Ltd, Weifang 262737, Shandong, China
  • Published:2025-10-17

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摘要： 为获得稳定的乳液结构,进一步发挥其在活性物质包封及输运中的作用,通过两步乳化法制备水包油包水(W1/O/W2)型双重乳液,并将其进行凝胶化得到乳液凝胶。以辛癸酸甘油酯(ODO)为油相,聚甘油蓖麻醇酸酯(PGPR)和十六烷基三甲基溴化铵(CTAB)原位修饰的纳米二氧化硅颗粒分别作为W1/O、O/W2乳液的界面稳定剂,考察乳化剂用量及油水比例对乳液类型、微观结构及稳定性的影响,确定制备稳定的W1/O及O/W2乳液的最佳配比。在此基础上,将一步乳化得到的W1/O乳液作为分散相,W2作为连续相,进一步乳化制备水包油包水(W1/O/W2)型双重乳液。通过在外水相(W2)中添加结冷胶,构筑结构稳定的乳液凝胶体系,其在室温放置60 d后,乳液微观结构未发现明显变化。本研究通过将外水相凝胶化获得稳定性良好的双重乳液凝胶体系,为活性物质封装和缓释等载体体系的应用开发提供有益的参考。

关键词: 双重乳液, 乳液凝胶, 稳定性, 原位修饰

Abstract: In order to obtain the stable emulsion structures to further improve the performance in encapsulation and transport for active substances, a water-in-oil-in-water(W1/O/W2)type double emulsion was successfully constructed by a two-step emulsification method, and the emulsion gel was obtained through a gelation process. The polyglycerol polyricinoleate(PGPR)and silica nanoparticles modified with hexadecyl trimethyl ammonium bromide(CTAB)were respectively used as stabilizers for W1/O and O/W2 emulsions, andoctyl and decyl glycerate(ODO)was used as the oil phase. The effect of emulsifier dosage and oil-water ratio on the emulsion type, droplet microstructure and emulsion stability were investigated to obtain the optimal conditions for preparing stable W1/O and O/W2 emulsions.On this basis, the W1/O emulsion from single-step emulsification was used as the dispersed phase with W2 as the continuous phase for the preparation of stable water-in-oil-in-water(W1/O/W2)double emulsions.The emulsion gels with excellent stability were obtained by introducing Gellan gum(GG)into the outer water phase, with no observed microstructural change after kept for 60 days at room temperature. In this study, the stable double emulsion gel system formed by gelation of the external aqueous phasewere hopefully helpful for the applications in encapsulation and release of active substances using emulsions as carriers.

Key words: double emulsions, emulsion gel, stability, modification

中图分类号: 

  • O648
[1] LAMBA H, SATHISH K, SABIKHI L. Double emulsions: emerging delivery system forplant bioactives[J]. Food and Bioprocess Technology, 2015, 8(4):709-728.
[2] KUMAR A, KAUR R, KUMARV, et al. New insights into water-in-oil-in-water(W/O/W)double emulsions: properties, fabrication, instability mechanism, and food applications[J]. Trends in Food Science &Technology, 2022, 128:22-37.
[3] GUO J X, CUI L J, MENG Z. Oleogels/emulsion gels as novel saturated fat replacers in meat products: a review[J]. Food Hydrocolloids, 2023, 137:108313.
[4] LIN D Q, KELLY A L, MIAO S. Preparation, structure-property relationships and applications of different emulsion gels: bulk emulsion gels, emulsion gel particles, and fluid emulsion gels[J]. Trends in Food Science & Technology, 2020, 102:123-137.
[5] FLAIZ L, FREIRE M,COFRADES S, et al. Comparison of simple, double and gelled double emulsions as hydroxytyrosol and n-3 fatty acid delivery systems[J]. Food Chemistry, 2016, 213:49-57.
[6] SHU J X, MCCLEMENTS D J, LUO S J, et al. Effect of internal and external gelation on the physical properties, water distribution, and lycopene encapsulation properties of alginate-based emulsion gels[J]. Food Hydrocolloids, 2023, 139:108499.
[7] ADITYA N P, ADITYA S, YANG H, et al. Co-delivery of hydrophobic curcumin and hydrophilic catechin by a water-in-oil-in-water double emulsion[J]. Food Chemistry, 2015, 173:7-13.
[8] DECARVALHO-GUIMAR(~overA)ESF B, CORREA K L,DE SOUZA T P, et al. A review of Pickering emulsions: perspectives and applications[J]. Pharmaceuticals, 2022, 15(11):1413.
[9] XIAO J, LU X X, HUANG Q R. Double emulsion derived from kafirin nanoparticles stabilized Pickering emulsion: fabrication, microstructure, stability and invitro digestion profile[J]. Food Hydrocolloids, 2017, 62:230-238.
[10] SPYROPOULOS F, DUFFUS L J, SMITH P, et al. Impact of Pickering intervention on the stability of W1/O/W2double emulsions of relevance to foods[J]. Langmuir, 2019, 35(47):15137-15150.
[11] BINKS B P, DESFORGES A, DUFF D G. Synergistic stabilization of emulsions by a mixture of surface-active nanoparticles and surfactant[J]. Langmuir, 2007, 23(3):1098-1106.
[12] PARIA S, KHILAR K C. A review on experimental studies of surfactant adsorption at the hydrophilic solid-water interface[J]. Advances in Colloid and Interface Science, 2004, 110(3):75-95.
[13] 陈钊,蒋建中,崔正刚. 表面活性剂-纳米颗粒相互作用与智能体系的构建(II)相反电荷表面活性剂-纳米颗粒相互作用(i):开关转移构建开关性Pickering乳状液和Pickering泡沫[J]. 日用化学工业, 2019, 49(8):492-502. CHEN Zhao, JIANG Jianzhong, CUI Zhenggang. Interactions between surfactants and nanoparticles and the construction of smart systems(Ⅱ). Interaction of the nanoparticle with an oppositely charged ionic surfactant(ⅰ): construction of switchable Pickering emulsions and Pickering foams via switch transference[J]. China Surfactant Detergent & Cosmetics, 2019, 49(8):492-502.
[14] BINKS B P, RODRIGUES J A, FRITH W J. Synergistic interaction in emulsions stabilized by a mixture of silica nanoparticles and cationic surfactant[J]. Langmuir, 2007, 23(7):3626-3636.
[15] MORAIS J M, ROCHA-FILHO P A, BURGESS D J. Influence of phase inversion on the formation and stability of one-step multiple emulsions[J]. Langmuir, 2009, 25(14):7954-7961.
[16] CLEGG P S, TAVACOLI J W, WILDE P J. One-step production of multiple emulsions: microfluidic, polymer-stabilized and particle-stabilized approaches[J]. Soft Matter, 2016, 12(4):998-1008.
[17] DING Shukai, SERRA C A, VANDAMME T F, et al. Double emulsions prepared by two-step emulsification:history, state-of-the-art and perspective[J]. Journal of Controlled Release, 2019, 295:31-49.
[18] CHEN M M, LI W T, WANG W B, et al. Effects of gelation on the stability, tribological properties and time-delayed release profile of double emulsions[J]. Food Hydrocolloids, 2022, 131:107753.
[19] CHEN X, MCCLEMENTS D J, ZHU Y Q, et al. Gastrointestinal fate of fluid and gelled nutraceutical emulsions:impact on proteolysis, lipolysis, and quercetin bioaccessibility[J]. Journal of Agricultural and Food Chemistry, 2018, 66(34):9087-9096.
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